Fertility
Conditions
Keywords
fertility preservation, oocyte cryopreservation, vitrification, egg freezing, fertility preservation in female cancer patients
Brief summary
The purpose of this study is to preserve the fertility potential in females diagnosed with cancer by vitrifying (rapidly freezing) their oocytes (eggs) before undergoing treatment for their cancer.
Interventions
PROCEDUREoocyte vitrification
freezing of the patient's retrieved oocytes via vitrification (rapid freezing)
Sponsors
Northwell Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
14 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* Patients must be 14-42 year old females with a cancer diagnosis. * Clearance letter from treating oncologist. * Approval by program oncologist or her designee. * Informed consent has to be signed after consultation with the program physician. Minors require consent of a parent or a legal guardian and assent from the participant. * Life expectancy (predicted by their malignancy) of 5 or more years. * Cancer diagnosis should have an expected cure rate of 50% or more, based upon clinico-pathologic features.
Exclusion criteria
* Patients whose oncologist and the program oncologist concur that immediate oncologic care should be rendered, not allowing sufficient time for a course of gonadotropin therapy and egg retrieval. * FSH level \>20 MIU/ml, indicating abnormal ovarian function. * Patients with stage IV cancers (\*age appropriate women with stage IV advanced Hodgkin's Lymphoma will be considered, as there is a significant long term survival rate with this advanced disease). * Patients with incurable cancer diagnoses. * Patients who are unable or unwilling to sign the informed consent. * Women cannot have an embryo transfer beyond age 50.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| successful pregnancy | nine months after transfer of embryo(s) | the primary objective of this study is the establishment of a successful pregnancy, following a disease-free interval after treatment for her cancer; this interval will be patient-dependent and will undoubtedly vary between participants. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| impact of stimulation on cancer recurrence | 5 years after treatment | patients will be followed for five years following cancer treatment to assess the risks associated with ovarian stimulation and the recurrence of cancer. |
Countries
United States
Outcome results
None listed