Exercise Capacity in Bronchiectasis Resection

Impact of Pulmonary Resection on Exercise Capacity in Patients With Bronchiectasis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01268475

Enrollment

Registered

2010-12-30

Start date

2009-03-31

Completion date

Unknown

Last updated

2010-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiectasis

Keywords

Bronchiectasis, Quality of Life, Respiratory Function Tests, Exercise Test

Brief summary

Bronchiectasis can be defined as an abnormal and irreversible dilatation of the bronchial tree due to repeated cycles of inflammation and infection, resulting in progressive loss of lung function. The surgical treatment by pulmonary resection or even lung transplantation is indicated in cases of bronchiectasis primary nonresponsive to appropriate medical treatment, or when associated with serious complications. There are few literature data on the influence of bronchiectasis in exercise capacity, quality of life and functional capacity, and the impact of lung resection in patients with this diagnosis. The primary objective of this study is to evaluate prospectively the impact of lung resection on exercise capacity in patients with clinical and radiological diagnosis of bronchiectasis. The secondary objective of this study is to evaluate the impact of lung resection on quality of life and lung function and to analyze the the presence of predictors of postoperative functional deterioration and the occurrence of complications.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Clinical and radiographic diagnosis of bronchiectasis; * Lack of adequate response to clinical treatment after 1 year of follow-up and / or presence of disease complications; * Agreement to participate of the study by signing of the Informed Consent Term

Exclusion criteria

* Comorbidities that prevent the patient to undergo general anesthesia; * Musculoskeletal and/or psychomotor disability to perform pulmonary function tests and cardiopulmonary exercise tests; * Inability to understand the quality of life questionnaires; * Age over 90 years or less 18 years.

Design outcomes

Primary

Measure	Time frame	Description
Impact of Pulmonary Resection on Exercise Capacity	Change from Baseline in Exercise Capacity at 3 months and Change from Baseline in Exercise Capacity at 9 months	Exercise Capacity will be assessed using Cardiopulmonary Exercise Test.

Secondary

Measure	Time frame	Description
Impact of Pulmonary Resection on Quality of Life.	Change from Baseline in Quality of Life at 3 months and Change from Baseline in Quality of Life at 9 months.	Quality of life will be assessed using WHOQOL-Bref and SF-36 questionnaries.
Impact of Pulmonary Resection on Lung Function.	Change from Baseline in Lung Function at 3 months and Change from Baseline in Lung Function at 9 months.	Lung Function will be assessed using Spirometry Test.

Countries

Brazil

Contacts

Primary ContactRicardo Mingarini Terra, MD, PhD

rmterra@uol.com.br55 11 3069597

Outcome results