Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity

Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity. Influence of Low Respiratory Rate With Unchanged Minute Volume.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01267916

Enrollment

Registered

2010-12-29

Start date

2011-01-31

Completion date

2011-12-31

Last updated

2012-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anesthesia, Laparoscopic Cholecystectomy

Keywords

intrinsic positive end-expiratory pressure, obesity, ventilator setting, respiratory rate

Brief summary

It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Detailed description

Impaired gas exchange is a common anesthetic problem in obese subjects. It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEPi) is present in grossly obese subjects especially in the supine position. It is known that there is a significant negative correlation between PEEPi present and PaO2. Therefore, the investigators postulated that if the reduce the PEEPi by reducing the respiratory rate in obese subjects, the impaired gas exchange might improve. The investigators tried to research the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Interventions

DEVICERR 6 + 0

Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 0

DEVICERR 10 + 0

Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 0

DEVICERR 16 + 0

Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 0

DEVICERR 6 + 5

Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 5

DEVICERR 10 + 5

Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 5

DEVICERR 16 + 5

Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 5

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

SINGLE (Caregiver)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* ASA class I or II obesity, Body-mass index \> 27.5 undergoing laparoscopic cholecystectomy

Exclusion criteria

* patients with severe cardiopulmonary disease peak inspiratory pressure \> 40 in the study setting

Design outcomes

Primary

Measure	Time frame	Description
Gas change parameters	15 minute interval	PaO2 and PaCO2 the result of arterial blood gas analysis

Secondary

Measure	Time frame	Description
intrinsic positive end-expiratory pressure	every 15 minutes	PEEPi measured by expiratory port occlusion method

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026