The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01267786

Enrollment

Registered

2010-12-29

Start date

2010-12-31

Completion date

Unknown

Last updated

2010-12-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Apoptosis, Liver Surgery

Keywords

Oxidotic stress

Brief summary

The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Interventions

PROCEDURELiver surgery

hepatectomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing liver surgery

Exclusion criteria

* ASA IV, Cardiovascular diseases

Design outcomes

Primary

Measure	Time frame	Description
Oxidotic stress after hepatectomy.	5 d postop.	Perioperative liver and renal biopsies and follow up with liver renal function tests plus intraoperative and postoperative cardiovascular monitoring

Secondary

Measure	Time frame	Description
Liver and renal dysfunction	5 d	liver and renal impairment due to ischemic injury

Countries

Greece

Contacts

Primary ContactGeorgios P Fragulidis, MD

gfragulidis@aretaieio.uoa.gr+30 6072910955

Backup ContactAikaterini D Melemeni, MD, DESA

amelemeni@med.uoa.gr+30 6946194817

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026