Uremia
Conditions
Keywords
dialysis, hemodialysis, Effect of recycled low-volume dialysate on dialysis efficacy
Brief summary
The purpose of this study is to investigate whether recycled dialysis fluid can supply enough clearance for hemodiaysis patients.
Detailed description
Conventional hemodialysis uses large amounts of water, which hinders travel possibilies for home hemodialysis (HD) patients. We have developed a recycling system using 25-30 l dialysate per dialysis. In vitro investigations show that this results in adequate dialysis. 12 HD patients will be studied during two dialysis sessions. The first HD will be a conventional 4 hour dialysis, using single pass dialysate. The second will be an 8-hour HD using multipass (recycled) dialysate 25-30 l. Clearance of urea, creatinine, phosphate and cobalamin will be measured both in the patient and the dialysate. Patient symptoms will be recorded.
Interventions
DEVICEMultipass hemodialysis
8-hour dialysis using a recycled dialysis bath of 25-30 l
Sponsors
Flexdialysis ApS
Herlev Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Stable chronic HD patients * Informed consent
Exclusion criteria
* Age \<18 years * Psychiatric disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urea Kt/V | 9 hours |
Secondary
| Measure | Time frame |
|---|---|
| Creatinine clearance | 9 hours |
| Patient symptoms | 9 hours |
Countries
Denmark
Outcome results
None listed