Heart Surgery
Conditions
Keywords
heart surgery
Brief summary
It has been repeatedly demonstrated that cardiac surgery with the use of extracorporeal circulation elicits a systemic inflammatory response and provokes ischemia-reperfusion related oxidative stress which could further lead to the development of organ failure in critically ill patients. Perioperative levels of macrophage migration inhibitory factor (MIF) and other inflammatory mediators could be involved in adverse outcomes in cardiac surgery.
Detailed description
The trace element selenium (Se) serves as an essential co-factor for the antioxidant enzymes Thioredoxin - reductase (TRR) and many other antioxidant enzymes, which protect tissues from oxidative stress. In septic patients it has previously been shown that thioredoxin, a TRR regulated Redox Enzyme, has the ability to suppress the synthesis of MIF. Aim of the present study is therefore to investigate the relation between perioperative selenium decrease and the reduction of TRR activity with a possible release of MIF during the inflammatory response after cardiac surgery.
Interventions
PROCEDUREBlood sampling
Blood sampling at various time points. Additional 92 mL blood.
Sponsors
RWTH Aachen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* more than 18 years of age * open heart surgery and use of heart-lung-device * informed consent has been obtained
Exclusion criteria
* under 18 years of age * emergency cases * informed consent cannot be obtained * pregnancy or patient is breast-feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pilot study: correlation between clinical and lab parameters | two months | To assess the importance of the MIF ligand/receptor family in a large cohort of patients (n=100) undergoing cardiac surgery and to characterize the underlying molecular events. Possible correlation between several clinical and laboratory parameters will be analyzed. This is a pilot study to generate hints at future items to be studied in controlled trials. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Secondary Outcome | two months | * Correlation between perioperative MIF and MIF-2 levels and postoperative outcome * Measurement of sCD74/MIF complex * Determination of MIF polymorphism and its significance on clinical outcome * perioperative inflammation * organ injury |
Countries
Germany
Outcome results
None listed