The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01267305

Enrollment

362

Registered

2010-12-28

Start date

2011-01-31

Completion date

2013-08-31

Last updated

2014-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism

Keywords

esophagectomy, lung resection, venous thromboembolism, low molecular weight heparin, chest drainage, TEG

Brief summary

The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.

Interventions

DRUGFondaparinux

2.5mg IH qd(8AM) after operation

DRUGNadroparin Calcium

4100AxaIU IH qd(8AM) after operation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* clinical diagnosis of esophageal carcinoma and planned for esophagectomy * clinical diagnosis of lung carcinoma and planned for lung resection * general anesthesia combined with epidural anesthesia

Exclusion criteria

* blood clotting disfunction before surgery * anticoagulating or antiplatelet history before surgery * low blood platelets count * hemorrhagic disease * cerebral hemorrhage * cerebral,spinal,ophthalmologic operation history * peptic ulcer * bleeding\>400ml in operation * bleeding\>100ml/h after operation * blood transfusion in or after operation * severe renal or liver disfunction * severe hypertension

Design outcomes

Primary

Measure	Time frame	Description
TEG values	three days after surgery	1.5ml aterial blood sample will be obtained daily for TEG , and the vulues of TEG,such as R,K,Alpha angle,MA,G,CI ,will be measured

Secondary

Measure	Time frame	Description
bleeding quantity of chest drainage	three days after surgery	all drain from chest tube are gathered and hematocrits are measured to calculate the quantities of bleeding
incidence rate of deep venous thromboembolism（DVT)	after surgery up to 7 days	incidence of DVT is measured by vascular ultrasonography
inhospital mortality	after surgery up to 28 days	the number of death in the period of hospital stay

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026