Hospital-acquired Pneumonia
Conditions
Keywords
Hospital-acquired pneumonia, E test, Antibiogram, Bronchoalveolar lavage
Brief summary
To rapidly adapt or deescalate the initially broad antibiotic treatment, an antibiogram analysis is required. E test strips have successfully provided an antibiogram 24 h after having been directly applied to bronchoalveolar lavage (BAL). An open-label, prospective cohort study of consecutive patients with hospital-acquired pneumonia will be conducted with the aim of validating a new method increasing the rapidity of antibiogram analysis compared to standard methods of culture. This antibiogram will be provided by E test strips directly applied to bronchoalveolar lavage (BAL) samples and analyzed from the 6th up to the 24th hour after its completion. The occurrence of major errors (S with E test method, I or R with standard method) and minor errors (I or R with E test method and S with standard method)will be observed and a comparison of H6, H10 and H24 results performed.
Interventions
OTHERE test method
E test strips directly applied to BAL
Sponsors
Université Victor Segalen Bordeaux 2
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all patients with suspected HAP undergoing BAL will be eligible
Exclusion criteria
* contraindications for BAL (PaO2/FIO2 \<100, risk of bronchoscopy-related haemorrhagic complications), secondary exclusion of patients with negative cultures, defined by a threshold of bacteria \<104 CFU/ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major error defined as the MIC(s) classified as R or I by E test method and S by referent method | 2 days |
Secondary
| Measure | Time frame |
|---|---|
| Minor error defined as the MIC(s) classified as R or I by E test method and S by referent method | 2 days |
Countries
France
Outcome results
None listed