Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01266343

Enrollment

Registered

2010-12-24

Start date

2007-01-31

Completion date

2009-12-31

Last updated

2010-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Primary Angle-closure Glaucoma, Glaucoma

Keywords

Glaucoma, anterior chamber paracentesis, conventional Mannitol infusion

Brief summary

The investigators wanted to reported the results of immediate anterior chamber paracentesis (ACP), compared to Mannitol infusion, in patients with acute primary angle-closure glaucoma (PACG). In this study, the investigators first divided patients into three sub-groups according to their initial intraocular pressure (IOP) for analyzing the differences of IOP control, severity of corneal edema, waiting time for laser peripheral iridotomy (LPI), and visual outcome between ACP and Mannitol infusion.

Detailed description

The investigators demonstrated that ACP could be first considered in patients with initial IOP between 45 to 60 mmHg because it provided better visual outcome than Mannitol infusion through the rapid stabilization of the anterior segment, which was achieved by rapid IOP control, better corneal edema regression, shortening waiting time for LPI. However, ACP should be considered in patients with the initial IOP of 60mmHg and higher only when Mannitol was contraindicated.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* first attack of acute PACG; * initial presenting IOP was higher than 45 mmHg; * diagnosis confirmed by gonioscopic examination; * patients within 48 hours of symptom onset.

Exclusion criteria

* been incompletely followed up within 2 weeks; * been using anti-glaucomatous medication before ACP or Mannitol infusion; * previous intraocular surgeries on the same eye; * contraindication for Mannitol; * history of other vision-threatening ocular diseases.

Countries

Taiwan

Outcome results