Healthy Volunteers
Conditions
Keywords
Brain-derived neurotrophic factor (BDNF), Platelets, Aspirin, Clopidogrel
Brief summary
The impact of anti-platelet drugs on the concentrations of Brain-derived neurotrophic factor (BDNF) in human plasma and serum is unknown. It is the aim of this study to investigate the impact of a single dose of Aspirin (500 mg) or Clopdigrel (600 mg) on the concentrations of Brain-derived neurotrophic factor (BDNF) in plasma and serum of healthy volunteers.
Interventions
Intake of 500 mg Aspirin on day 1. Intake of 600 mg Clopidogrel on day 28. Blood collection for the measurement of platelet inhibition, platelet counts and BDNF, TGF-beta, 5-HT concentrations in peripheral blood on day 1 (before intake of 500 mg Aspirin), day 2 (24 hours after intake of 500 mg Aspirin), day 28 (before intake of 600 mg Clopidogrel), day 29 (24 hours after intake of 600 mg Clopidogrel).
Sponsors
University of Rostock
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-50 years * Gender: Male
Exclusion criteria
* Any acute disease * Any chronic disease * Any medication * Allergies / Intolerance in association with Aspirin or Clopidogrel
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BDNF plasma and serum concentration 24 hours after Aspirin or Clopidgrel intake | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| 5-HT and TGF-beta concentrations 24 hours after Aspirin or Clopidgrel intake | 24 hours |
Countries
Germany
Outcome results
None listed