Knee Arthroplasty, Postoperative Pain
Conditions
Keywords
Adductor-Canal-Blockade, postoperative pain, US-guided nerve block, total knee arthroplasty
Brief summary
The objective of this study is to assess the efficacy of Adductor-Canal-Blockade on pain and morphine consumption after total knee arthroplasty. Our hypothesis is that the Adductor -Canal-Blockade is superior to placebo in reducing pain and morphine consumption after total knee arthroplasty.
Interventions
US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml
PROCEDUREAdductor-Canal-blockade with saline
US-guided Adductor-Canal-blockade with saline
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Total Knee Arthroplasty in general anaesthesia * ASA 1-3 * BMI 18-40 * Written informed consent
Exclusion criteria
* Can not cooperate to the exam * Do not speak or understand Danish * Drug allergy * Alcohol or drug abuse * Daily consumption of strong opioids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain during 45 degrees active flexion of the knee | 1 hour postoperative | 0-100 mm at a visual analogue scale (VAS), at 1 hour postoperative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain during rest | 1-6 hours postoperative | 0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as the area under the curve (AUC) for the interval 1-6 hours postoperative. |
| A change in pain score in the ropivacaine group, after activating the block | 30-60 minutes postoperative | 0-100 mm at a visual analogue scale (VAS), at 30 and 60 minutes postoperative. A change in pain score in the ropivacaine group compared to the placebo group, after activating the block. |
| Total morphine consumption | 30 minutes - 6 hours postoperative | Total morphine consumption at the interval 30 minutes - 6 hours postoperative. |
| Pain during 45 degrees active flexion of the knee | 0-6 hours postoperative | 0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as the area under the curve (AUC) for the interval 1-6 hours postoperative. |
| Postoperative vomiting | 1-6 hours postoperative | Number of vomiting episodes at the interval 1-6 hours postoperative. |
| Zofran consumption | 1-6 hours postoperative | Total zofran consumption at the intervals 1-6 hours postoperative. |
| Sedation | 1-6 hours postoperative | Sedation score (0-3) registered at 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as the mean value for the interval 1-6 hours postoperative. |
| Postoperative nausea | 1-6 hours postoperative | Nausea scores(0-3)registered at 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as mean value for the interval 1-6 hours postoperative. |
Countries
Denmark
Outcome results
None listed