Hypoxia
Conditions
Keywords
hypoxia, O2 diffusion and convection, cardiac output, PEEP, Effects of hypoxia
Brief summary
Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.
Detailed description
Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing. Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max). FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.
Interventions
DEVICEthreshold PEEP
Various set of pressures : 0, 5, 10 cm H20; pursed lips breathing
Sponsors
AGIR à Dom
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
: * active (\> 2 hrs/week physical activity) * adult * non smoking volunteers
Exclusion criteria
: * cardiac, respiratory, neuromuscular, metabolic pathology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SpO2 | mean over 1 minute | after three minutes of PEEP vs spontaneous breathing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| peripheral HbO2/DeoxyHb | 1 min | after three minutes of PEEP / PLB vs. spontaneous breathing |
| cardiac output | mean over 1 min | after three min of PEEP vs. spontaneous breathing |
| pattern of breathing (fR, VT, PETCO2) | 1 min | after three min of PEEP vs. spontaneous breathing |
Countries
France
Contacts
Primary ContactBernard Wuyam, MD, PhD
Outcome results
None listed