Carbon Dioxide Insufflation (CO2) and Warm Water Infusion (WWI) Versus Standard Air Insufflation (AI) for Unsedated Colonoscopy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01259583

Enrollment

341

Registered

2010-12-14

Start date

2010-07-31

Completion date

2010-12-31

Last updated

2013-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Warm Water, CO2 Colonoscopy, Unsedated Colonoscopy

Brief summary

Due to the increasing demand for colonoscopy in clinical practice, great interest has recently renewed for unsedated colonoscopy. Both Carbon dioxide Insufflation (CO2) and Warm Water Infusion (WWI) have been advocated to improve patient tolerance for colonoscopy as compared to standard Air Insufflation (AI). This study is aimed at evaluating the performance of the above techniques versus AI in unsedated patients.

Interventions

PROCEDURECO2

CO2 insufflation

PROCEDUREWarm water

warm water irrigation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* adult outpatients willing to undergo colonoscopy without routine initial sedation

Exclusion criteria

* refuse to initiate colonoscopy without routine sedation * inadequate bowel preparation * incapacity to give informed consent

Design outcomes

Primary

Measure	Time frame
number of patients undergoing complete unsedated colonoscopy	6 months

Secondary

Measure	Time frame
evaluation of pain and tolerability scores	6 months

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026