Mycoplasma Pneumonia
Conditions
Keywords
macrolide- resistant Mycoplasma pneumoniae,, Mycoplasm pneumonia antibiotic therapy
Brief summary
Mycoplasma pneumoniae, an important pathogen of community acquired pneumonia,are becoming more and more resistant to macrolide. The study aim is to optimize anti-infection therapy.
Detailed description
Mycoplasma pneumoniae was one of important atypical pathogens of community acquired pneumonia. As lack of cell wall, β-lactam medicines were invalid, however, macrolides, tetracyclines and quinolones were effective. But from 2001, many countries reported macrolide- resistant Mycoplasma pneumoniae. Typically, erythromycin was first-line antibiotic medicine. With the resistance increasing, Mycoplasm pneumonia treatment will become more and more difficult. Thus, optimization of Mycoplasm pneumonia antibiotic therapy is very important.
Interventions
DRUGMoxifloxacin
0.4 Qd for 7days
DRUGCephalosporins and azithromycin
cefuroxime 1.5 bid for 7 days plus azithromycin 0.5 qd for 7 days
Sponsors
Capital Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Confirmed community acquired pneumonia 2. 60ys≥age≥18 ys 3. Respiratory symptom (cough accompanied by little or no sputum) 4. New infiltration showed by chest radiology(x-ray or CT) 5. Lung signs was not obvious 6. White blood cell\<10,000/mm3 7. Without underlying diseases or mild
Exclusion criteria
1. Age\<18ys or \>60ys 2. Pregnancy or breast-feeding 3. Over one week after the onset of symptoms 4. HIV infection 5. Recent 90-day hospitalized history(length of stay greater than 2 days) 6. Live in nursing homes or rehabilitation hospitals 7. Taken macrolides or quinolones medicines before enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to resolution of fever (defined as the period from start of study-drug to relief of fever) | one month | usually duration of fever is about one to two weeks |
| Time to resolution of fever (defined as the period from onset to relief of fever) | one month | usually duration of fever is about one to two weeks |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of antibiotics change | one year |
| Duration of antibiotics | one year |
| Time to resolution of respiratory symptoms(defined as the period from start of study-drug to relief of symptoms) | one year |
| Proportion of resolution of fever after antibiotics therapy for 72 hours | one year |
| Antibiotic-related adverse reaction | one year |
| Proportion of resolution of fever after antibiotics therapy for 24 hours | one year |
| Time to resolution of respiratory symptoms(defined as the period from onset to relief of symptoms) | one year |
Countries
China
Outcome results
None listed