Investigation of Human Alpha-fetoprotein Genes

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01258894

Enrollment

300

Registered

2010-12-13

Start date

2010-12-31

Completion date

2013-10-31

Last updated

2010-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elevated or Normal Alpha-fetoprotein Patients

Brief summary

Studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, this study will recruit the patients and their family with elevated AFP (\>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed.

Detailed description

Abnormal AFP elevation was usually noted in liver regeneration, HCC, nonseminomatous germ cell tumors or other malignant tumors. However, some studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, we study will recruit the patients and their family with elevated AFP (\>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed. The hypothesis of this study is that the mutation of AFP gene might be one of the causes of abnormal AFP.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* The patients and their family with elevated AFP (\>20 ng/mL) and normal AFP patients being control groups. More than 20 years old

Exclusion criteria

* Pregnancy

Countries

Taiwan

Contacts

Primary ContactJin Chuan Sheu, M.D. Ph.D.

celian0916@yahoo.com.tw

Outcome results