Atrial Fibrillation, Genetic Predisposition to Disease, Heart; Dysfunction Postoperative, Cardiac Surgery, Heart Failure, Myocardial Infarction
Conditions
Brief summary
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.
Detailed description
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. In addition, we also examine blood and urine biomarkers (proteins).
Interventions
None listed
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Texas Heart Institute
University of Texas Southwestern Medical Center
Johns Hopkins University
Brigham and Women's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Undergoing heart surgery * Willing to provide consent
Exclusion criteria
* Enrolled in a concurrent drug or device trial that precludes concurrent enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality (i.e. number of participants who are deceased during postoperative day 0 up to year 5) | Day of procedure to year 5 | Data will be collected from electronic medical records; data points to be collected for this measurement include serum creatinine. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Presence of Arrhythmia (i.e. number of patients who develop an arrhythmia after their cardiac surgery) | Day of procedure to year 5 | Data will be collected from electronic medical records; data points to be collected for this measurement include post-procedural EKG reports and progress notes. |
| Myocardial Infarction (i.e. number of participants who develop a MI during postoperative day 0 to year 5) | Day of procedure to year 5 | Data will be collected from electronic medical records; data points to be collected for this measurement include post-procedural EKG reports, cardiac enzyme values, progress notes, and cardiac catheterization reports. |
| Heart failure per NYHA class II, III, IV | Day of procedure to year 5 | This will be measured in accordance to New York Heart Association Guidelines. |
| Acute Kidney Injury using KDIGO criteria: albumin/creatinine ratio (>/= 300 mg/g) and eGRF (< 60 mL/min/1.73^2) | Day of procedure to post procedure day 7 | Data will be collected from electronic medical records; data points to be collected for this measurement include serum creatinine. |
| Quality of Life Survey - The Seattle Angina Questionnaire (SAQShortForm) | Administered once prior to the procedure and 1 month to 5 years after hospital discharge | A questionnaire to assess for angina |
| Quality of Life Survey - 12-item short form health survey (SF12) | Administered once prior to the procedure and 1 month to 5 years after hospital discharge | A questionnaire to assess for overall health |
| Quality of Life Survey - The Kansas City Cardiomyopathy Questionnaire (KCCQShortForm) | Administered once prior to the procedure and 1 month to 5 years after hospital discharge | A questionnaire to assess for heart failure |
Countries
United States
Outcome results
None listed