Stable Angina Pectoris
Conditions
Brief summary
This study includes patients with stable coronary artery disease without previously known myocardial infarction, and investigates the prevalence of clinically unrecognized myocardial damage and its prognostic implication.
Detailed description
A substantial portion of all myocardial infarctions are not clinically recognized, but the myocardial damage can be recognized afterwards e g by magnetic resonance imaging (MRI). This study includes patients with stable coronary artery disease without previously known myocardial infarction, and investigates the prevalence of clinically unrecognised myocardial damage (UMI), and the prognostic value of UMI regarding new cardiac events. In a subset of the patients, the biologic intra-individual variability of troponin and other biochemical markers will be investigated (substudy protocol).
Interventions
None listed
Sponsors
Uppsala University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* symptoms of stable angina pectoris according to the treating physician * scheduled for coronary angiography * written informed consent
Exclusion criteria
* pathological Q-wave in the 12-lead resting ECG * known previous myocardial infarction * previous PCI (percutaneous coronary intervention) or CABG (coronary artery bypass graft) * history of congestive heart failure * anything that contraindicates a MRI investigation (e.g. pacemaker, claustrophobia, intracranial clips) * lack of suitability for participation in the trial, for any reason, as judged by the Investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac events defined as a composite of death, resuscitated cardiac arrest, spontaneous acute myocardial infarction and hospitalisation for congestive heart failure or unstable angina. | 24 months |
Secondary
| Measure | Time frame |
|---|---|
| Presence of unrecognized myocardial infarction | Baseline |
| Size and localisation of unrecognized myocardial infarction | Baseline |
| Degree and localization of artherosclerotic lesions at a coronary angiogram | Baseline |
| Procedure related acute myocardial infarction | 5 years |
| Left ventricular mass and dimensions, levels of troponin and other biochemical markers, electrocardiography (ECG), anthropometric data | Baseline |
| Long-term mortality, cardiac mortality and incidence of acute myocardial infarction | 5 years |
Countries
Sweden
Contacts
Primary ContactBertil Lindahl, professor
Outcome results
None listed