Bile Duct Cancer
Conditions
Keywords
immunonutrition, hepatectomy, Th1, Th2
Brief summary
The purpose of this study is to determine whether preoperative immunonutrition is effective on infectious complication and Th1/Th2 differentiation in patients with major hepatectomy.
Detailed description
The investigators reported that preoperative immunonutrition improve the incidence of postoperative infectious complication in patients after hepatectomy, and modulation of Th1/Th2 differentiation may play important roles in this effect. Object of this study is to investigate the effects of preoperative immunonutrition on incidence of postoperative infectious complication, and Th1/Th2 balance after hepatectomy.
Interventions
DIETARY_SUPPLEMENTOral IMPACT
oral supplement for 5 days(1L/day) before surgery of a formula enriched with arginine, omega-3 fatty acids, and RNA
Sponsors
Chiba University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* hepatectomy
Exclusion criteria
* age younger than 18 years * ongoing infection * gastrointestinal obstruction * respiratory dysfunction * cardiac dysfunction * hepatic dysfunction * renal failure * history of recent immunosuppressive or immunological disease * preoperative evidence of widespread metastatic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative infectious complication | 30 days |
Secondary
| Measure | Time frame |
|---|---|
| plasma IL-6, CRP, Th1/Th2 balance | 14 days |
Countries
Japan
Outcome results
None listed