Nerve Growth Factor in Chronic Pancreatitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01255917

Enrollment

Registered

2010-12-08

Start date

2008-02-29

Completion date

2011-08-31

Last updated

2016-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Pancreatitis

Keywords

Tio identify role of NGF in pain in CP, Identify biomarkers related to progression of CP

Brief summary

This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis. Hypothesis: 1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is not only a mechanical problem 2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is variably expressed in different morphological stages of CP and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients with established CP and none of the

Exclusion criteria

mention below.

Design outcomes

Primary

Measure	Time frame
The levels of NGF in subjects with different morphological stages of chronic pancreatitis (CP) will be compared to the controls and in each morphological stage of CP will be correlated with pain scores.	5 years

Secondary

Measure	Time frame
Correlate the expression of NGF and other inflammatory cytokines in the pancreatic juice in each morphological stage of CP.	5 years

Countries

United States

Outcome results