Non-small Cell Lung Cancer, Primary Carcinoma
Conditions
Keywords
Genome-wide association studies(GWAS), Single nucleotide polymorphism(SNP), Lung cancer
Brief summary
To study the association of Genetic Polymorphisms with Lung Cancer Risk in Tianjin Population.
Detailed description
Eligibility criteria: * nonsmoker * female * age between 35 and 80 * no other types of tumors history * frequency-matched cases and controls on gender and age Outcome measures: * OR(odds ratio) * RR(risk ratio) * CI(confidence interval) * SAS software
Interventions
None listed
Sponsors
Tianjin Medical University Cancer Institute and Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Non-small cell lung cancer * Age from 35 to 80 years old * Female * Non-smokers * Frequency-matched on age and gender
Exclusion criteria
* Previous medical history of cancer * Previous radiotherapy * Previous chemotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia | 2011-12 | A GWAS reported a novel association between the TP63 locus and risk of lung adenocarcinoma; however, this association did not achieve genome-wide significance among never-smoking males or females. We genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 500 never-smoking female lung cancer cases and 500 never-smoking female controls from China. Genetic variation in rs10937405 was associated with lung adenocarcinoma. Our findings provide strong evidence that genetic variation in TP63 is associated with risk of lung adenocarcinoma among non-smoking females. |
Countries
China
Contacts
Primary ContactChen Kexin, M.D., Ph.D
Outcome results
None listed