Uterine Hemorrhage
Conditions
Brief summary
This study aims to test the effect of Doxycycline in treatment of uterine bleeding during the use of injectable contraception that contains one hormone progesterone only.
Interventions
DRUGDoxycycline
100 mg Doxycycline capsules twice daily for 5 days
DRUGPlacebo
Placebo capsules twice daily for 5 days
Sponsors
Omar Mamdouh Shaaban
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Women under DMPA contraception for at least one month. 2. Accept to participate in the trial after receiving adequate information about the trial including information that she is a part of randomization comprising the possibility of receiving new treatment for bleeding or inactive ingredients. 3. Women's ability to keep an accurate menstrual diary for the study.
Exclusion criteria
1. Lactating women for the fear of the effect of tetracycline on the breast-fed infant. 2. Patients with already diagnosed local gynecological abnormality. 3. Women receiving treatment for bleeding within the last one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stoppage of bleeding within 7 days | 7 days from starting of tretment |
Secondary
| Measure | Time frame |
|---|---|
| Next bleeding free interval | 3 month |
| Uterine bleeding patterns in the next 3 months after treatment | 3 months |
| Number of days needed to stop a current attack of bleeding | 1 month |
| Side effects encountered during treatment | 5 days |
| Discontinuation of the DMPA and its reason | 3 months |
| Women satisfaction with the treatment she received | 3 months |
Countries
Egypt
Outcome results
None listed