Type 2 Diabetes
Conditions
Keywords
Herbal medicine; Type 2 diabetes; Gynostemma pentaphyllum Tea; Insulin sensitivity;
Brief summary
The aim of the present study was to investigate the effects of Gynostemma Pentaphyllum tea on insulin sensitivity in drug-naïve type 2 diabetic patients.
Detailed description
In Vietnam, traditional herbal medicines have played a major role in the management of diabetes for centuries. Gynostemma Pentaphyllum (GP) Makino (Family Cucurbitaceae) is a perennial creeping herb growing wild in the mountainous regions of Vietnam, China and some other Asian countries and was widely used in Southeast Asian countries as an herbal medicine and being beneficial for the prevention and treatment of diabetes. We have previously published the evidences that GP tea possessed anti-diabetic effect with good safety data in newly diagnosed T2D patients, and had effect on insulin sensitivity. In addition extract of GP had been shown to reduce both hyperglycemia and hyperlipidemia in diabetic Zucker Fatty rats. So the present study was to investigate the effects of Gynostemma Pentaphyllum tea in insulin sensitivity in type 2 diabetic patients.
Interventions
DIETARY_SUPPLEMENTGynostemma Pentaphyllum tea
6g/day per oral, twice a day in 10 weeks, 30 minutes before breakfast and dinner
DIETARY_SUPPLEMENTPlacebo tea
6g/day per oral, twice a day in 10 weeks, 30 minutes before breakfast and dinner
Sponsors
Karolinska Institutet
Swedish International Development Cooperation Agency (SIDA)
Hanoi Medical University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Newly diagnosed, drug-naive patients with type 2 diabetes * Fasting plasma glucose: 7-11 mmol/l * HbA1C: 7-9%.
Exclusion criteria
* Type 1 diabetes * Liver and kidney failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fating plasma glucose, Steady state plasma glucose in Somatostatin-Insulin-Glucose Infusion Test | 10 weeks | All subjects participated in Somatostatin-Insulin-Glucose Infusion Test (SIGIT), lasting 150 minutes, performed at 8am after an 8-10h overnight fast with only tap water allowed ad libitum. Somatostatin was used to suppress endogenous insulin release, thereby allowing estimation of sensitivity to exogenously administered insulin by measuring blood glucose value at 90, 120 and 150 minute of the test (SIGIT mean). |
Secondary
| Measure | Time frame |
|---|---|
| Liver enzymes (ALT, AST) | 10 weeks |
| Kidney function (S-creatinine, S-BUN) | 10 weeks |
| Plasma lipids (TG, Cholesterol, HDL-, LDL-) | 10 weeks |
| Blood pressure | 10 weeks |
| Body weight (BMI, hip-waist ratio) | 10 weeks |
Countries
Vietnam
Outcome results
None listed