Acute Lymphoblastic Leukemia, Cancer, Obesity
Conditions
Keywords
obesity, text messages, internet, cancer, overweight
Brief summary
UC San Diego researchers conducted a study to develop and evaluate an internet and text message based weight loss study for childhood acute lymphoblastic leukemia (ALL) survivors. We hypothesized that those study participants randomized to the intervention will demonstrate greater reduction in BMI-z score as compared to the control group.
Detailed description
The PACE CALL or Fit4Life study, sponsored by the American Cancer Society , was a 4-year research project aimed at developing and testing the efficacy of a web & cell phone based weight loss program. The purpose of the intervention was to promote weight loss and management and improve physical activity, diet and sedentary behaviors among preadolescent and adolescent youth (7-18) who are survivors of childhood ALL (defined as being off therapy for at least 2 years without disease relapse). Fit4Life was based on and adapted from notable prior successful adolescent weight control interventions, and physical activity and diet behavioral promotion interventions in the preadolescent and adolescent age group. Particular sensitivity to issues experienced by cancer survivors and their families were incorporated into this newly developed intervention based on systematic cancer survivor input and feedback as well as mentor/collaborator input regarding cancer survivor research.
Interventions
BEHAVIORALPACE CALL/Fit4Life
The Fit4Life E intervention will be designed to promote weight loss and subsequent weight loss maintenance through the adoption and maintenance of improved eating, physical activity and sedentary behaviors in at risk for overweight and overweight adolescent survivors of ALL and their parent/guardian. the Fit4Life intervention will incorporate elements of the Chronic Care Model, including frequent phone and mail interactions, an initial in-person encounter to provide encouragement and initial patient-tailored counseling for obesity management, family-centered skill development to achieve healthy behavioral modification via goal setting, self-monitoring, and problem solving. The Fit4Life intervention includes: Web-based weight loss program Text and Picture messages Counseling Calls Health Coach
Sponsors
University of California, San Diego
Huang, Jeannie, M.D.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
7 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* 7 - 18 years old * survived childhood acute lymphoblastic leukemia (defined as being off treatment for at least 2 years) * greater than or equal to 85th percentile BMI-for-age and gender) * read and speak English * have a parent that reads and speaks English or Spanish * willingness to attend assessments * access to the Internet
Exclusion criteria
* any comorbidities of obesity that require immediate sub-specialist referral including pseudotumor cerebri, sleep apnea, and obesity hypoventilation syndrome * any subject with a known disease of the liver, pancreas or small intestine that would adversely effect digestion or absorption of nutrients * any pulmonary, cardiovascular, orthopedic, or musculoskeletal problem that would limit ability to adhere to moderate-level physical activity recommendations * have a history of substance abuse or other psychiatric disorder that would impair compliance with the study protocol * are using any medications which alter body weight * are currently enrolled in another weight loss program * in foster care
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BMI | Baseline, 4 months | To determine the impact of a weight loss intervention on BMI compared to a control group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Weight Loss Behaviors | Baseline, 4 months | To determine the impact of a weight loss intervention vs. a control group on self-reported behavioral measures of diet and physical activity. |
| Metabolic Blood Measures | Baseline, 4 months | To determine the impact of a weight loss intervention vs. control on fasting serum insulin, fasting blood glucose, and blood lipid levels. |
| Psychosocial Mediators of Weight Loss Behaviors | Baseline, 4 months | To determine the impact of a weight loss intervention vs. control on psychosocial mediators of diet and physical activity behavior changes |
| Quality of Life | Baseline, 4 months | To determine the impace of a weight loss intervention vs. control on quality of life and depression. |
Countries
United States
Outcome results
None listed