Improvement of Cardiovascular Autonomic Control, Reduction of Levels of Catecholamines
Conditions
Keywords
Transcutaneous electrical nerve stimulation, Sympathetic nervous system, Parasympathetic nervous system, heart rate
Brief summary
The purpose of this study is to determine acute effect the transctutaneous electrical nerve stimulation in sympathetic and parassympathetic system in individuals with heart failure.
Detailed description
Heart failure (HF) is the inability of the heart to maintain adequate levels of blood supply to tissues. In recent years there has been an increased prevalence of heart failure (HF), in Brazil there are about two million people diagnosed with HF and 240,000 new cases per year. Thus, the IC constitutes the most serious problem now and in the fields of cardiology and public health. Sympathetic activity is increased and correlates with a worse prognosis and survival in these patients. Currently, the pharmacological blockade of the sympathetic system by chronic use of beta-blockers are commonly used to treat hyperactivity, but these interventions have side effects. The transcutaneous electrical nerve stimulation (TENS) has been used successfully to control pain in different clinical conditions and may be a noninvasive strategy to reduce drug and not the severity of increased sympathetic.
Interventions
OTHERtranscutaneous electrical nerve stimulation
Application of low frequency (10-Hz) and high frequency (100-Hz) TENS, in two different days
Sponsors
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Instituto de Cardiologia do Rio Grande do Sul
Federal University of Health Science of Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Possess stable heart failure grade II or III according to NYHA; * Ejection fraction \<40% determined by echocardiography; * Having no change in drug therapy one month before being included in the study; * There have been Myocardial Infarction (AMI) three months before study entry;
Exclusion criteria
* Patients with grade IV heart failure according to NYHA; * Acute respiratory; * Unstable angina; * Ventricular arrhythmia, unstable until three months before the start of the study; * Pacemaker; * Active smoking; * Diabetes mellitus; * And fever or infectious disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| differences in blood levels of catecholamines differences in blood levels of catecholamines differences in blood levels of catecholamines Differences in blood levels of catecholamines | one minute before and after transutaneous electrical nerve stimulation intervention (acute effect) | For evaluation of catecholamines (epinephrine, norepinephrine and dopamine) will be held one antecubital venipuncture and collected into tubes containing ethylenediaminetetraacetic acid (EDTA). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| improvement of heart rate variability | one minute before and after transcutaneous electrical nerve stimulation intervention (acute effect) | Temporal series of the tachogram, related to each selected segment were evaluated quantitatively considering the values of HR, total and normalized powers of low frequency (LF - 0.04 to 0.15 Hz) and high frequency (HF - 0.15 to 0.40 Hz) components of HRV and the sympato-vagal index (LF/HF). |
Countries
Brazil
Outcome results
None listed