Ductus Arteriosus, Patent
Conditions
Brief summary
Patent ductus arterious(PDA)is frequently seen and potentially pathologic in preterm infants. Near-infrared spectroscopy is a simple bedside tool to analyse the changes in the renal and splanchnic tissue oxygenation index and fractional tissue oxygen extraction and may be helpful to measure effects of ibuprofen treatment for PDA in preterm infants.
Detailed description
Patent ductus arterious (PDA) is the most common cardiovascular abnormality in preterm infants.There are clear associations between a PDA and decreased renal and splanchnic blood flow. The aim is to monitor, using near-infrared spectroscopy, the effect of ibuprofen on the fractional tissue (renal and mesenteric) oxygen extraction (FTOE) in preterm newborns during ibuprofen of the treatment PDA.
Interventions
Non-invasive monitoring device measures the quantity of reflected light photons as a function of two wavelengths, and determines the spectral absorption of the underlying tissue.
Sponsors
Zekai Tahir Burak Women's Health Research and Education Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Days to No maximum
Healthy volunteers
No
Inclusion criteria
* Gestational age \<32 weeks and \<1500 g * Echocardiographic evidence of hemodynamically significant patent ductus arterious
Exclusion criteria
* Major congenital anomalies * Intraventricular hemorrhage of grade 3 within the previous 24 hours * Serum creatinine level 1.5 mg%,serum urea nitrogen concentration \>50 mg%, * Platelet count 60 000/mL3, a tendency to bleed (defined by the presence of hematuria, blood in the endotracheal aspirate, gastric aspirate, or stools and/or oozing from puncture sites) * Hyperbilirubinemia necessitating exchange transfusion
Countries
Turkey (Türkiye)
Outcome results
None listed