Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01251510

Enrollment

Registered

2010-12-02

Start date

2010-10-31

Completion date

2011-06-30

Last updated

2013-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Brief summary

PURPOSE The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology. In the present study the investigators examine the GLP-1 secretion in healthy subjects and cholecystectomised patients. Thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished GLP-1 response as compared to healthy subjects.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

(Healthy) * Normal fasting plasma glucose * Normal glucose tolerance * Normal haemoglobin levels * Informed content Inclusion Criteria: (cholecystectomy group) * Laparoscopic cholecystectomy \<6 months. Indication: Gallstones. * Normal fasting plasma glucose * Normal glucose tolerance * Normal haemoglobin levels * Informed content

Exclusion criteria

(both groups) * Diabetes * Pre diabetes (impaired glucose tolerance or impaired fasting glucose) * 1st degree relatives with diabetes * Obesity (BMI \> 30) * Inflammatory bowels disease * Nephropathy * Liver disease * Medication which cannot be on hold for 24h

Design outcomes

Primary

Measure	Time frame
GLP-1 secretion	Postprandial

Countries

Denmark

Outcome results