Asthma, Mouse Allergen Exposure, Mouse Allergy
Conditions
Keywords
asthma, mouse allergen, environmental intervention
Brief summary
The MAAIT is a randomized, controlled trial of a home intervention to reduce mouse allergen exposure in mouse allergic children with asthma and mouse allergen exposure. Participants will be randomized to either the Integrated Pest Management (IPM) Group or the Education Group. The IPM Group will receive professional mouse abatement, education, two HEPA filters, allergen-proof mattress and pillow encasements, and targeted cleaning. The Education Group will receive education about IPM at the beginning of the trial and then after completion of the trial, will receive the IPM intervention. Participants will be followed for 12 months.
Interventions
The IPM intervention will include professional mouse abatement, two HEPA filters, targeted cleaning, education about IPM, and allergen-proof mattress and pillow encasements. The intervention will be delivered at baseline to the IPM Group, and then repeated if recurrent or persistent mouse infestation is present.
OTHEREducation
This group will receive education about mouse IPM.
Sponsors
Boston Children's Hospital
Columbia University
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* persistent asthma * exacerbation, previous 12 months * evidence of mouse sensitization * high levels of mouse allergen in home * ages 5-17 years
Exclusion criteria
* intermittent asthma * no exacerbation in previous 12 months * not sensitized to mouse * low or undetectable mouse allergen in home * other lung disease aside from asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in asthma symptoms | 0, 3, 6, 9, 12 months | days of asthma symptoms |
Countries
United States
Outcome results
None listed