Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
Conditions
Keywords
high volume hemofiltration, sepsis, acute kidney injury, survival
Brief summary
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
Interventions
OTHERextra high volume hemofiltration
extra high volume hemofiltration (85 mL/kg/h, EHVHF)
high volume hemofiltration (50 mL/kg/h, HVHF)
Sponsors
Zhejiang University
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
met at least one of the following criteria: oliguria (urine output less than 100 mL in a 6 h period and unresponsive to fluid resuscitation), serum potassium concentration more than 6.5 mmol/L, severe acidemia (pH \< 7.2), serum creatinine more than 250 µmol/L, or presence of severe organ edema (e.g. pulmonary edema).
Exclusion criteria
* were presence of a malignant tumor, chronic renal insufficiency (serum creatinine \>133 µmol/L), or receiving any kind of renal replacement therapy before randomization.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 90 days survival | — | The primary study outcome was death from any cause within 90 days. Results were analyzed by Kaplan-Meier survival curves |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of stay in the ICU and hospital | — | Secondary outcomes were length of stay in the ICU and hospital and renal outcome of survivors at 90 days after randomization. |
Countries
China
Outcome results
None listed