Cephalosporin Allergy, Non-immediate Drug Reactions
Conditions
Keywords
Cephalosporins, Drug hypersensitivity
Brief summary
This study aims to compare the results of skin testing and ELISPOT assay in patients with a history of non-immediate reactions to cephalosporins
Detailed description
Patients with a history of non-immediate reactions to cephalosporins will be tested by patch test and/or intradermal test. Peripheral blood mononuclear cells will be collected to analyzed cytokine secretions by ELISPOT assay
Interventions
PROCEDURESkin tests and ELISPOT assay
Patch test and/or intradermal test will be performed in patients as well as cytokine secretions from PBMCs will be analyzed by ELISPOT assay
Sponsors
Chulalongkorn University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Patients with a history of non-immediate hypersensitivity reactions to cephalosporins 2. At least 18 years of age
Exclusion criteria
1. Suffering from severe systemic disease/ in bad health 2. Being pregnant 3. Patients with a history of immediate reactions to cephalosporin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The skin testing results of Cephalosporin skin test compared to ELISPOT assay | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| The result of cross reactivity between Cephalosporins and other Betalactams determined by skin testing and ELISPOT assay | 1 year |
Countries
Thailand
Outcome results
None listed