Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone?

Does Administration of Etomidate and Propofol if the Anesthetic Induction of the Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngosacopy, When Compared to Propofol or Etomidate Alone?

Status

Withdrawn

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01248234

Enrollment

Registered

2010-11-25

Start date

2012-07-31

Completion date

2012-07-31

Last updated

2012-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

elderly, hypertensive, anesthesia

Brief summary

This study will attempt to show that a combination of drugs, Etomidate and Propofol, provide a more stable blood pressure when used to put elderly hypertensive patients to sleep than either drug used alone.

Detailed description

Same as above.

Interventions

DRUGpropofol

Propofol 1mg/kg will be given once to put the patient to sleep for surgery.

DRUGEtomidate

Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery.

DRUGPropofol and Etomidate

Etomidate 0.2mg/kg plus Propofol 0.5mg/kg will be given once to put the patient to sleep for surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

65 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Patients at least 65 years old, with a history of hypertension.

Exclusion criteria

* Patients less than 65 years old or without a history of hypertension.

Design outcomes

Primary

Measure	Time frame	Description
Blood pressure stability during anesthetic induction	15 minutes	Blood pressure will be measures every minute for 15 minutes following anesthetic induction

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026