Acute Coronary Syndrome, Angioplasty
Conditions
Keywords
rosuvastatin, angioplasty, acute coronary syndrome
Brief summary
Rosuvastatin reload may prevent myocardial damage in ACS patients undergoing PCI
Interventions
DRUGadditional rosuvastatin loading
additional rosuvastatin (10mg p.o.)is given at 18 hours and 4-6 hours before PCI
DRUGplacebo control
sugar pill is given 18-24hr and 4-6hr before PCI as control
Sponsors
Beijing Anzhen Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* 18-75 year old * diagnosed as acute coronary syndrome * Plan to PCI
Exclusion criteria
* STEMI patient * emergency PCI(\<2h) for NSTE-ACS * History of liver disease and myopathy (ALT/AST\>3 x upper limit of normal,CK\>5 x upper limit of normal) * TG\>500mg/dl,CCr\<30ml/min * inflammatory disease * allergic to rosuvastatin * nephrotic syndrome,hypothyroidism,systemic lupus erythematosus,myeloma,et.al.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| peri-procedural myocardial damage | 48 hours after PCI |
Secondary
| Measure | Time frame |
|---|---|
| MACE | 30 days after PCI |
Countries
China
Contacts
Primary ContactShujjuan Cheng, MD, PhD
Backup ContactShiying Li, MD
Outcome results
None listed