Infertility
Conditions
Brief summary
Scratching the linning of the womb before IVF cycle could increase the chances of having a baby after an IVF cycle.
Detailed description
All women with history of RIF (as defined by ESHRE) and who wish to undertake another assisted conception treatment cycle are invited to participate in the trial. Women will be randomised to two arms; one undergoing endometrial sampling and control. Women in the experimental arm will be subjected to endometrial scrapping with Pipelle biopsy catheter two times; on days 21 and 26 of the cycle prior to the IVF index cycle and after initiation of the GnRHa in the long agonist protocol. Women in the control group will undergo a placebo procedure using the uterine sound on the same days of the cycle like women in the intervention group.
Interventions
PROCEDUREscratching
endometrial scratching before COH in IVF
PROCEDUREA PLACEBO PROCEDURE
A PLACEBO PROCEDURE
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 40 Years
Healthy volunteers
No
Inclusion criteria
WOMEN WITH PREVIOUS IVF FAILURE UNDERGOING IVF TREATMENT \-
Exclusion criteria
* WOMEN\>40 YEARS OLD WOMEN UNDERGOING THEIR FIRST IVF TREATMENT CYCLE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| live birth rate per woman | 9 months |
Secondary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rate | 12 weeks |
Countries
Egypt
Outcome results
None listed