Pain and Schizophrenia

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01244542

Enrollment

Registered

2010-11-19

Start date

2011-08-31

Completion date

2015-01-31

Last updated

2017-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Schizophrenia

Keywords

Schizophrenia, DSM IV criteria, Pain insensitivity, Painful perception, Opioid receptors

Brief summary

The aim of the investigators project is to explore the mechanisms of pain insensitivity in patients with schizophrenia, in order to prevent its invalidating consequences. The investigators will couple methods of experimental psychology with EEG and blood samplings, in order to distinguish the role of non-painful perception, attention, aversive effects, and pain expression, and the investigators will explore an original neurobiological hypothesis regarding the activation of opioid receptors.

Interventions

OTHERunpleasant stimuli

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with schizophrenia (criteria DSM IV) or healthy controls matched with patients on age, sex and education level * 18-55 years old

Exclusion criteria

* Past history affecting CNS * Intake of psychotropic drugs, except for patients * Metabolic disorder affecting sensory processing (diabetes) * Intake of benzodiazepines

Design outcomes

Primary

Measure	Time frame	Description
Unpleasant stimuli	during experimental session	acute electrical stimulation

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026