Moderate Hypertriacylglycerolemic Subjects
Conditions
Keywords
n3 LC-PUFA, yoghurt, inflammatory markers
Brief summary
The effective dosage of a n3-LC-PUFA intervention (with n3 LC-PUFA-enriched yoghurt) on the modulation of cardiovascular risk factors and inflammatory biomarkers were determined.
Detailed description
Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 150 mg/dL (1.7 mmol/L)) participated on the placebo-controlled, double-blind, parallel designed study. The subjects consumed placebo yoghurt (1), or n3 LC-PUFA-enriched yoghurt (0.8 g n3 LC-PUFA/d (2), 3 g n3 LC-PUFA/d (3)) for 10 weeks. Blood samples were taken at the beginning and at the end of the period. Parameters: * Blood lipids (total cholesterol, HDL, LDL, triacylglycerols) * Fatty acid distribution of plasma lipids (PL) and erythrocyte membranes (EM) * Concentrations of eicosanoids (PGs, HETEs) * Production of ex vivo stimulated cytokines by T cells * SNPs in the CD36 genotype
Interventions
DIETARY_SUPPLEMENTn3 long chain polyunsaturated fatty acids
Group 1 (placebo) Group 2 (0.8 g n3 LC-PUFA/d in 125 g yoghurt) Group 3 (3 g n3 LC-PUFA/d in 200 g yoghurt)
Sponsors
University of Jena
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* hypertriacylglycerolemic subjects (TAG: ≥ 150 mg/dl (1.7 mmol/l))
Exclusion criteria
* patients receiving blood-diluting and lipid-lowering medications or glucocorticoids * patients suffering from gastrointestinal or metabolic diseases (e.g., diabetes mellitus, hyper- and hypothyroidism) and hypercholesteremic patients with familial previous impacts * patients taking dietary supplements (e.g., fish oil capsules, vitamin E) or having either known allergies or foodstuff indigestibility * further
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood lipids (total cholesterol, HDL, LDL, triacylglycerols) | change from baseline after 10 weeks | change from baseline after 10 weeks Group 1: placebo Group 2: 0.8 g n3 LC-PUFA/125 g yoghurt per day Group 3: 3 g n3 LC-PUFA/200 g yoghurt per day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fatty acid distribution in plasma lipids and erythrocyte membranes, eicosanoids in plasma, production of ex vivo stimulated cytokines by T cells, SNPs on CD36 genotype | change from baseline after 10 weeks | change from baseline after 10 weeks Group 1: placebo Group 2: 0.8 g n3 LC-PUFA/125 g yoghurt per day Group 3: 3 g n3 LC-PUFA/200 g yoghurt per day |
Countries
Germany
Outcome results
None listed