Cytokine Changes After Colorectal Cancer Resection

Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01244022

Enrollment

Registered

2010-11-19

Start date

2010-08-31

Completion date

2012-12-31

Last updated

2013-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

Colorectal cancer, Surgical stress response, interleukins

Brief summary

Based on our previous research, this study aims to determine reliable surgical stress response markers in patients undergoing radical resection of colorectal cancer.

Detailed description

Every surgical intervention represents a stress for patient's organism. During the operation, numerous changes in the patient's metabolism take place, that are termed surgical stress response. Leading cause of surgical stress response is tissue destruction that always accompanies operations. Surgical stress response is effected through activation of hypothalamus-pituitary-adrenal axis and through sympathetic activation. The consequences of surgical stress response are numerous. Surgical stress response is essential to uneventful postoperative recovery. On the other hand, excessive surgical stress response may lead to serious postoperative complications, such as heart and kidney failure, venous thrombosis, disruption of operative wound and wound infection. In prior studies the investigators have shown the kinetics of postoperative serum interleukin changes after radical resection of gastric cancer. This study aims at determining reliable markers of surgical stress response severity in patients undergoing radical resection of colorectal cancer.

Interventions

PROCEDUREcolorectal cancer resection

Open radical resection of colorectal cancer, according to oncological principals, depending on the tumor site

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Pathohistologically verified colorectal cancer

Exclusion criteria

* Distant metastases noticed before or during surgery * History of autoimmune diseases or immunodeficiencies * Use of immunomodulatory drugs within 1 year prior to surgery

Design outcomes

Primary

Measure	Time frame	Description
Postoperative changes of serum cytokine levels	1 day, 2 days and 7 days postoperatively	Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values.

Secondary

Measure	Time frame
Early postoperative complications	Within one month after surgery

Countries

Croatia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026