Acute Respiratory Failure
Conditions
Keywords
Acute respiratory failure, Oxygen therapy delivery systems, Non invasive ventilation, High concentration mask, Hypoxemic pneumonia
Brief summary
The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation).12 immunocompetent patients will compare the successive use of oxygen therapy delivery systems Optiflow®/Ospal® and 12 immunodeficient patients will compare the successive use of systems Optiflow®/Non invasive ventilation.
Interventions
OTHEROxygen therapy delivery systems
T-60 (minutes) : clinical examination, blood gas, electrocardiogram; T0 / First oxygen therapy delivery system: clinical examination, blood gas, electrocardiogram, measurement of positive and expiratory pressure and FiO2; T10 : blood gas; Between T0 and T60 (every 10 minutes): clinical examination, measurement of positive and expiratory pressure and FiO2; T60 / Second oxygen therapy delivery system: clinical examination, blood gas, electrocardiogram, measurement of positive and expiratory pressure and FiO2; T70 : blood gas; Between T60 and T120 (every 10 minutes): clinical examination, measurement of positive and expiratory pressure and FiO2; T120: clinical examination, blood gas, electrocardiogram, measurement of positive and expiratory pressure and FiO2
Sponsors
Nantes University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient hospitalized in the intensive care unit of Nantes University Hospital * Signed informed consent * Patient with not hypercapnic acute hypoxemic respiratory failure * Immunocompetent and immunodeficient patient
Exclusion criteria
* Age \< 18 years * Pregnancy * Contra-indication to non invasive ventilation * Allergy to xylocaine * Coagulation troubles * Tracheotomized patient * Urgent indication to intubation * Hypercapnic acute respiratory failure * Acute pulmonary edema * Face or nose malformation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Calcul of the ratio PaO2/FiO2 | one hour after each system used | The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation) by calculating the ratio PaO2/FiO2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| number of participants with adverse events | — | The secondary outcomes are to understand the mechanisms of action of Optiflow system and to evaluate the tolerance of this system: * number of adverse events: respiratory events, trophic troubles, subjective events (comfort, dryness of mucous membranes, gastric distension, preferred system), serious hemodynamic and cardiovascular events * impact on work of breathing: measure of respiratory frequency and blood gas * measure of positive and expiratory pressure |
| measure of respiratory frequency and blood gas | — | The secondary outcomes are to understand the mechanisms of action of Optiflow system and to evaluate the tolerance of this system: * number of adverse events: respiratory events, trophic troubles, subjective events (comfort, dryness of mucous membranes, gastric distension, preferred system), serious hemodynamic and cardiovascular events * impact on work of breathing: measure of respiratory frequency and blood gas * measure of positive and expiratory pressure |
| measure of positive and expiratory pressure | — | The secondary outcomes are to understand the mechanisms of action of Optiflow system and to evaluate the tolerance of this system: * number of adverse events: respiratory events, trophic troubles, subjective events (comfort, dryness of mucous membranes, gastric distension, preferred system), serious hemodynamic and cardiovascular events * impact on work of breathing: measure of respiratory frequency and blood gas * measure of positive and expiratory pressure |
Countries
France
Outcome results
None listed