Borderline Personality Disorder, Effects of Oxytocin on Borderline Personality Disorder
Conditions
Keywords
Oxytocin, BPD, Borderline
Brief summary
RCT. Two substudies (clinical and experimental). Main objective of the trial is to examine if oxytocin, compared to placebo shows any additional effect on the therapy achievements (outcome) of patients with borderline personality disorder, who receive an in-patient standard psychotherapy (Dialectical-behavioral-therapy, Marsha Linehan (2006)). Secondary objectives : Investigate if oxytocin compared to placebo enhances social trust and emotion recognition in patients with borderline personality disorder. Comparison of the effects of Oxytocin on patients with BPD and major depression.
Interventions
DRUGOxytocin
Oxytocin
OTHERplacebo
placebo
Sponsors
Prof. Dr. Markus Heinrichs
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Gender: Both, male and female * Minimum Age: 18 Years * Maximum Age: 50 Years * Borderline personality disorder or major depression (clinical control group) * Mini Mental Status Test \> 27 (capacity to consent)
Exclusion criteria
* chronic or acute somatic health problems * Schizophrenia * Bipolar affective disorder * pregnancy * breast feeding * neurological disorder * allergy to antidegradants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BPD Symptoms | BPD Symptoms |
Countries
Germany
Outcome results
None listed