Effect of Acute Red Raspberry Consumption on Post-prandial Oxidative Stress

An Acute Intervention Study Investigating the Effect of Red Raspberry Consumption on Post-prandial Oxidative Stress

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01242033

Enrollment

Registered

2010-11-16

Start date

2010-02-28

Completion date

2010-03-31

Last updated

2010-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antioxidants, Oxidative Stress

Keywords

red raspberries, post-prandial, oxidative stress, antioxidants, polyphenols, vitamin C, acute dietary intervention

Brief summary

Eight healthy adult subjects will be given a meal of one, two or four cups red raspberries, or two slices white bread with or without 200 mg vitamin C, after an overnight fast and consumption of a low polyphenol diet for two days. Blood samples will be taken at various time points over an eight hour period to measure oxidative stress and antioxidant levels in the blood. Each subject will attend 5 study visits with one week intervals and be given each meal in a random order. It is hypothesized that raspberry consumption at higher doses will greater protect against meal-induced oxidative stress compared to bread controls.

Interventions

DIETARY_SUPPLEMENTred raspberries

single serving of one, two or four cups red raspberries

DIETARY_SUPPLEMENTbread controls

two slices white bread alone or with 200 mg vitamin C supplement

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy adults

Exclusion criteria

* blood pressure greater than 120/80 mm Hg * body mass index greater than 24.9 kg/m\^2 * history of any chronic disease * currently taking medications * allergy to fruit

Design outcomes

Primary

Measure	Time frame	Description
change in antioxidant capacity from baseline (-0.25 h)	-0.25, 0.25, 0.5, 1, 2, 4 hours post-intake	plasma antioxidant capacity measured using the 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation assay and expressed in Trolox Equivalents (TE)

Secondary

Measure	Time frame	Description
change in lipid peroxidation from baseline (-0.25 h)	-0.25, 0.25, 0.5, 1, 2, 4 hours post-intake	serum thiobarbituric acid reactive substances (TBARS) measured as an indicator of the lipid peroxidation product malondialdehyde (MDA)
change in thiols compared to baseline (-0.25 h)	-025, 0.25, 0.5, 1, 2, 4 hours post-intake	plasma thiols quantified by 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) assay as an indicator of the level of protection against protein oxidation

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026