The Effect of Heart Rate on Cardiac Index in Patients With Left Ventricular Hypertrophy

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01241838

Enrollment

Registered

2010-11-16

Start date

2011-02-28

Completion date

2012-08-31

Last updated

2012-08-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diastolic Dysfunction, Heart Failure, Heart Rate, Left Ventricular Hypertrophy

Keywords

Heart failure, Left ventricular hypertrophy, Diastolic dysfunction

Brief summary

The purpose of this study is to compare the effect of heart rate on cardiac index in patients with or without left ventricular hypertrophy. The study will be conducted in postoperative heart surgery patients with a pacemaker.

Interventions

DEVICEPacemaker

Routine postoperative temporary pacemaker Rate change of 65-80-95-110-125 beats/second in random order at day 3-4 after operation

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Scheduled heart surgery including thoracotomy * Ejection fraction \> 45% * Duration of QRS complex \< 120 milliseconds * Sinus rhythm * Planned perioperative temporary pacemaker Group: Left ventricular hypertrophy: Thickness of interventricular septum and posterior wall \>11 mm. Group: No left ventricular hypertrophy: Thickness of interventricular septum and posterior wall \<11 mm.

Exclusion criteria

* Active endocarditis * Severe mitral insufficiency * No patient consent

Design outcomes

Primary

Measure	Time frame
Cardiac index	At heart rates 65-80-95-110-125

Secondary

Measure	Time frame	Description
Ejection fraction	Heart rates of 65-80-95-110-120	Echocardiographic index of systolic function
Strain	Heart rates of 65-80-95-110-125	Echocardiographic index of systolic function
S-max	Heart rates of 65-80-95-110-125 beats per second	Echocardiographic index of systolic function
E/E'	Heart rates of 65-80-95-110-125 beats per second	Echocardiographic index of diastolic function
E/A ratio	Heart rates of 65-80-95-110-125 beats per second	Echocardiographic index of diastolic function
Mean arterial blood pressure	At heart rates 65-80-95-110-125	—
Isovolumetric relaxation index	Heart rates of 65-80-95-110-125 beats per second	Echocardiographic index of diastolic function
IVRT/IVRT'	Heart rates of 65-80-95-110-125 beats per second	Echocardiographic index of diastolic function
End diastolic volume	Heart rates of 65-80-95-110-125 beats per second	Volume of left ventricle and end diastole
End systolic volume	Heart rates of 65-80-95-110-125 beats per second	Volume of left ventricle at end systole
E'/A' ratio	Heart rates of 65-80-95-110-125 beats per second	Echocardiographic index of diastolic function

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026