The Effect of Chewing Gum on Small Bowel Transit Time

The Effect of Chewing Gum on Small Bowel Transit Time: a Prospective Randomized Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01241825

Enrollment

122

Registered

2010-11-16

Start date

2010-09-30

Completion date

2013-07-31

Last updated

2014-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel Transit Times

Keywords

capsule endoscopy, chewing gum, small bowel transit time

Brief summary

The purpose of this study is to see if chewing sugarless chewing gum alters the time it takes for a capsule endoscopy to travel through the stomach and small bowel, and to see if more/less capsule endoscopes reach the large bowel.

Detailed description

The subjects will include patients already referred to us for a capsule endoscopy (CE) in this unit. We have calculated how many patients we need from small bowel transit times from the last 100 patients who had a CE at our centre. We will include 122. These will be randomly divided into two groups. The patients (chew chewing gum) and the controls (do not chew chewing gum).

Interventions

OTHERTrident sugarless chewing gum.

Patients will be randomly divided into 2 groups, one subject group (these chew gum) and one control group (these do not chew gum). The subjects will have to chew Trident sugarless chewing gum for 20-30 minutes every 2 hours, all together 4 times at t=0 h, t=2, t=4 and t=6 h.

OTHEROne control group (these do not chew gum).

The control group will not chew chewing gum while undergoing capsule endoscopy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* All out-patients \> 19 years old presenting for capsule endoscopy

Exclusion criteria

* Patients on narcotics * Patients on motility enhancing and/or slowing drugs should stop these at least 5 days prior to the procedure or be excluded from the study. * Patients, who have proven or suspected obstruction of the bowel. * Patients, who have had prior small bowel and/or gastric surgery. * Patients with an ileostomy. * Patients who have a known and/or have a history of swallowing disorder * Patients with diabetes and/or hypo-/hyper- thyroidism * Patients in whom the capsule become impacted at a stricture (these patients will be taken out of the study and given the necessary medical/surgical treatment).

Design outcomes

Primary

Measure	Time frame
Small bowel transit time	6 hours

Secondary

Measure	Time frame
Gastric transit time, cecal completion rate	6 hours

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 22, 2026