Liver Fibrosis
Conditions
Keywords
liver fibrosis, survival, transient elastography
Brief summary
The aim of this prospective study was to compare the 5-year prognostic value of transient elastography (TE), FibroTest (FT), APRI , FIB-4, Lok, and Child-Pugh scores for predicting survival and complications of cirrhosis in patients with chronic liver diseases.
Detailed description
A total of 1616 patients with chronic hepatitis C was included. At 5 years, 79 patients were dead (39 liver-related deaths) and 16 patients had liver transplantation. Overall survival was 91.7% and survival without liver-related death 94.4%. Survival was significantly decreased in patients diagnosed with severe fibrosis, whatever the non-invasive method used. All these methods were able to predict a shorter survival in this large population. Patients had their prognosis decreased as liver stiffness increased. By multivariate analysis, only FibroTest \> 0.74 (OR 4.41, 95%CI 1.62-12.01, p=0.004) was associated with overall survival, and liver stiffness \> 9.5 kPa (OR 4.71, 95%CI 1.06-21.01, p=0.04) associated with liver-related death.
Interventions
None listed
Sponsors
Association HGE CHU Bordeaux Sud
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* chronic hepatitis C * chronic hepatitis B * alcoholic liver disease * non alcoholic steatohepatitis
Exclusion criteria
* ascitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Survival without liver complications | 3 months |
| Survival without liver transplantation | 3 months |
Countries
France
Outcome results
None listed