Appetite Regulation, Obesity
Conditions
Brief summary
The aim of the ProSat study is to examine the effects of a probiotic capsule containing Lb. Casei on subjective appetite sensation, ad libitum energy intake, and appetite hormone response in a single meal test and to determine whether the acute effects persist after daily supplementation of the probiotic capsule.
Interventions
DIETARY_SUPPLEMENTProbiotic
Parallel, randomized, controlled 2 arms study.
Sponsors
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women * Normal to slight overweight (BMI: 22-28 kg/m2) * 20-45 years of age
Exclusion criteria
* Smoking * Daily medicine use (oral contraceptives excluded) * Use of pre- and probiotic supplements and foods * Blood donation 3 months prior to the study * Hb \< 7,5mmol/l * Chronic illnesses such as hyperlipidemia, diabetes inflammatory diseases * Pregnancy or breastfeeding * Elite athletes (\>10 hours hard exercise/week) * Vegetarians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose, insulin, GLP-1, GLP-2, CCK, PYY, PP, ghrelin, amylin, LPS, TNF-alfa, CRP, fibrinogen. | June 2011 |
Secondary
| Measure | Time frame |
|---|---|
| Subjective appetite measurements, spontaneous food intake. | June 2011 |
Countries
Denmark
Outcome results
None listed