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The Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction

The Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01239524
Enrollment
28
Registered
2010-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2010-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction

Keywords

breast reconstruction, latissimus dorsi flap, thoracodorsal nerve, skeletal muscle disuse, breast MRI

Brief summary

Breast reconstruction with a pedicled myocutaneous latissimus dorsi (LD) flap is a widely used reconstruction method. It is controversial if surgical denervation by transecting the thoracodorsal nerve should be performed or not. It is assumed that after denervation the latissimus dorsi muscle will significantly atrophy and lose volume. On the other hand discomforting signs and symptoms from muscle contraction are believed to be prevented if flap is denervated. The aim of the study was prospectively evaluate the influence of LD-flap innervation on the functional and aesthetic outcome of delayed breast reconstruction, and to compare the change in muscle structure in breast MRI and histopathology.

Interventions

PROCEDUREdenervation of thoracodorsal nerve or saving the nerve

Sponsors

Tampere University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
20 Years to 70 Years

Inclusion criteria

* delayed LD-flap breast reconstruction, no recurrent disease observed

Exclusion criteria

* recurrent cancer, partial resection of the breast

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 20, 2026