Combined Nutrient Intake and Muscle Protein Synthesis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01239277

Enrollment

Registered

2010-11-11

Start date

2011-01-31

Completion date

2011-07-31

Last updated

2011-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging

Keywords

muscle, FSR, protein, carbohydrate, leucine

Brief summary

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Interventions

OTHERprotein

20g protein

OTHERprotein and carbohydrate

20g protein and 20g carbohydrate

OTHERprotein and leucine

20g protein, 2.5g leucine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

70 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* males * 70-85 years or 18-30 years * BMI \< 30

Exclusion criteria

* Type II diabetes * All co morbidities interacting with mobility and muscle metabolism of the lower limbs * Use of anticoagulants * Patients suffering from Phenylketonuria * Participation in any regular exercise programme

Design outcomes

Primary

Measure	Time frame	Description
Muscle protein synthesis	6 h postprandial period	Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026