Asthma, Children, Exhaled Breath Condensate, Home Monitoring, Non-invasive Inflammatory Markers, Volatile Organic Compounds
Conditions
Keywords
asthma, children, home monitoring, exhaled breath condensate, non-invasive inflammatory markers, volatile organic compounds
Brief summary
The purpose of the present proposal was to investigate the predictive properties of markers in exhaled breath to predict an asthma exacerbation. In addition, the reliability of home monitor assessments to measure asthma control will be examined.
Interventions
None listed
Sponsors
ZonMw: The Netherlands Organisation for Health Research and Development
Maastricht University Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
1. already known with a diagnosis of asthma during at least 6 months 2. age between 6 and 17 years 3. reversibility to a bronchodilator (increase in FEV1 \> 9% of predicted value and/or 4. bronchial hyperresponsiveness to histamine \< 8 mg/ml.
Exclusion criteria
1. cardiac abnormalities 2. mental retardation, congenital abnormalities or existence of a syndrome 3. active smoking 4. no technical satisfactory performance of measurements 5. no phone line or internet assess available at home.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of exacerbations | 1 year | increase of asthma symptoms, use of short b2-agonists, drop in FEV1% of maximum personal value. |
| asthma control | 1 year | asthma control questionnaire |
| Quality of life | 1 year | Asthma Quality of Life questionnaire for children |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cost-effectiveness | 1 year | incremental cost per exacerbation prevented |
Countries
Netherlands
Outcome results
None listed