Use of Lidocaine in Rapid Sequence Induction

Impact of Lidocaine on Anesthetic Depth During Rapid Sequence Induction

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01238718

Enrollment

Registered

2010-11-11

Start date

2008-10-31

Completion date

2011-07-31

Last updated

2011-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic Response

Keywords

lidocaine, anesthetic depth, hemodynamics, rapid sequence induction, BIS

Brief summary

Lidocaine has been shown to blunt the cardiovascular response to endotracheal intubation. The incidence of hypertension, tachycardia and dysrhythmias due to laryngoscopy may be increased in patients that receive rapid sequence induction and intubation, where opioids are spared and intravenous anesthetic agents are not titrated step by step. Our hypothesis was that lidocaine when administered intravenously in patients who undergo rapid sequence induction may not only blunt the hemodynamic response to intubation, but may also increase the anesthetic depth (as assessed by BIS), thus further reducing the possibility of hypertension, arrhythmias and also awareness.

Interventions

DRUGLidocaine

lidocaine 1.5 mg/kg intravenously

DRUGPlacebo

normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* reason for rapid sequence induction (emergency, reflux), * ASA I-II, * no antihypertensive drugs, * no antiarrhythmic drugs

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
BIS changes after lidocaine administration in rapid sequence induction	change from baseline in BIS values during 10 minutes

Secondary

Measure	Time frame
change in blood pressure	change from baseline in blood pressure during 10 minutes
change in Heart rate	change from baseline in heart rate durng 10 minutes

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026