Efficacy of a Propolis-based Denture Cleanser

Efficacy of a Propolis Solution for Cleaning Complete Dentures: a Randomized Crossover Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01237782

Enrollment

Registered

2010-11-10

Start date

2010-09-30

Completion date

2011-06-30

Last updated

2014-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Plaque, Denture Stomatitis, Oral Candidiasis, Oral Hygiene

Keywords

Candida, Complete Denture, Dental Plaque Index, Denture Bases, Denture Cleansers, Edentulous Mouth, Mutans Streptococci, Oral Health, Propolis, Streptococcus mutans

Brief summary

The purpose of this study is to assess if a propolis solution is able to remove plaque and kill microbes from complete dentures. The investigators will compare the results of the propolis-based denture cleanser with those obtained with an inactive solution.

Interventions

DRUGDenture soaking solution

Immersion of complete dentures in 200ml of a denture soaking solution for 20 minutes. Propolis solution: Spa Dent (Nissin Dental Products Inc., Kyoto, Japan).

DRUGSaline solution

Immersion of complete dentures in 200ml of a placebo denture soaking solution for 20 minutes.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

45 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Good general health * Patients requesting new complete dentures * Regular wearing of the same maxillary and mandibular complete dentures for at least one year * Both denture bases and artificial teeth should be composed by acrylic resin

Exclusion criteria

* Unsatisfactory complete dentures in use (i.e. with poor fitting, relining or fractures) * Pathologic changes in the oral cavity

Design outcomes

Primary

Measure	Time frame	Description
Denture plaque coverage area (%)	At the same day of the intervention, up to 1 hour following denture soaking	Relation between stained area and total surface area on the internal surface of maxillary complete dentures.

Secondary

Measure	Time frame	Description
mutans streptococci counts (CFU)	At the same day of the intervention, up to 1 hour following denture soaking	Microbial counts on maxilary denture base, as assessed by a conventional microbiological method.
Candida spp. counts (CFU)	At the same day of the intervention, up to 1 hour following denture soaking	Microbial counts on maxilary denture base, as assessed by a conventional microbiological method.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026