Limbal Deficiency, Severe Ocular Surface Damage
Conditions
Keywords
Ocular surface damage, Limbal deficiency, Cultivated corneal epithelial stem cell transplantation
Brief summary
The purpose of this study is to elucidate the appropriate condition of developing cultivated corneal epithelial graft and evaluate the surgical outcome of transplantation of the cultivated corneal epithelial stem cell in the patients.
Detailed description
Ocular surface damage caused by severe ocular surface diseases, particularly thermal and chemical burn or Stevens-Johnson syndrome result in corneal epithelial defect, corneal vascularization, corneal conjunctivalization and loss of transparency. Corneal limbal stem cell transplantation has been demonstrated to improve the outcome of ocular surface reconstruction. However, the conventional management of allograft limbal transplantation generally has unsatisfactory outcome because of high risk of rejection and requires long-life immunosuppressive medications.
Interventions
PROCEDURECultivated limbal transplantation
Cultivated corneal epithelial stem cell transplantation. Autograft, Living related allograft, and Cadaveric allograft
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Unilateral/Bilateral limbal stem cell deficiency proved by specific clinical features and impression cytology result
Exclusion criteria
* Age under 18 * Active ocular infection, Severe dry eye, Uncontrolled glaucoma * Immunocompromised host * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular surface status (signs of limbal deficiency and immunopathological markers) | Three years |
Countries
Thailand
Outcome results
None listed