Healthy
Conditions
Keywords
water pipe smoking, acute effect, Endothelial, healthy adults who smoke narghile
Brief summary
Title: The acute effect of narghile smoking on endothelial Function, and exhaled breath condensate (EBC) and pulmonary function tests in healthy volunteers. Objectives: To evaluate the acute effect of one cession of narghile smoking on endothelial Function, airway inflammation as assessed by exhaled breath condensate (EBC) in healthy volunteers. Design: Prospective study evaluating these parameters before and after 30 minutes of Narghile smoking. The changes in inflammatory parameters pre and post smoking will be evaluated blindly. Sample size: 50 participants Participant selection: Adults subjects who smoke Narghile . Intervention: Each subject will undergo evaluation including a respiratory questionnaire, endothelial Function , pulmonary function tests , exhaled breath condensate (EBC) and carboxy- hemoglobin levels . All measurements will be evaluated before and after one cession of 30 minutes narghile smoking.
Interventions
OTHERSmoking Narghile for 30 min
No Other intervention will be used
Sponsors
Rambam Health Care Campus
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \> 18 Y.O. * Have smoked Water-pipe at least once before.
Exclusion criteria
* Breast feeding Women. * S/P Bacterial Or Viral infection, Last 2 weeks * P.O. Steroids * Water-pipe smoking, last 24 hours * Cigarette smoking, last 6 hours * Intensive exposure to smoke (fire), last 24 hours * S/P Intensive Care Hospitalization, last 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PRE - Endothelial Function as assessed by EndoPAT2000 | baseline (before smoking narghile) | as assessed by EndoPAT2000. a pulse-oxymeter that asseses the endothelial function |
| POST - Endothelial Function as assessed by EndoPAT2000 | after 30 minutes of smoking narghile | as assessed by EndoPAT2000. a pulse-oxymeter that asseses the endothelial function |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analog Score 1-10 (1=bad 10=good) | before and immediatly after 30 min of smoking | Questionnaire |
| Respiratory Rate | before and immediatly after 30 min of smoking | — |
| Spirometry | before and immediatly after 30 min of smoking | Koko spirometry system |
| carboxy- hemoglobin | before and immediatly after 30 min of smoking | Blood Test |
| Blood Pressure | before and immediatly after 30 min of smoking | Regular Blood Pressure assesment |
| Exhaled Breath Condensate | before and immediatly after 30 min of smoking | R-tubes test |
| Eosinophils Count | before and immediatly after 30 min of smoking | Blood Test |
| heart rate | before and immediatly after 30 min of smoking | Heart Beats count |
Countries
Israel
Outcome results
None listed