Extrinsic Allergic Alveolitis
Conditions
Keywords
pigeon, bird fancier, extrinsic allergic alveolitis, BAL, broncho-alveolar lavage, elispot, antigen
Brief summary
The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens. The hypothesis is: cells in BAL lavage fluid from patients with EAA will be responsive to specific antigens and this response can be measured using ELISPOT.
Detailed description
Subjects suffering from extrinsic allergic alveolitis caused by pigeons will undergo a broncho alveolar lavage. Cells obtained from this BAL will be used for ELISPOT technique with pigeon specific antigens
Interventions
None listed
Sponsors
Bossink, A.W.J.
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* suspicion of pigeon induced extrinsic alveolitis
Exclusion criteria
* use of oral steroids * unable to give informed consent * age below 18
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ELISPOT response in cells obtained from broncho-alveolar lavage | 2 days | All elispots will be performed the same day, the end point will be available the next day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Elispot response in cells from blood | 2 days | ELispots will be performed the same day as blood collection, results will be available the next day |
Countries
Netherlands
Outcome results
None listed